Form: SC 13G/A

Schedule filed to report acquisition of beneficial ownership of 5% or more of a class of equity securities by passive investors and certain institutions

February 13, 2001

SC 13G/A: Schedule filed to report acquisition of beneficial ownership of 5% or more of a class of equity securities by passive investors and certain institutions

Published on February 13, 2001





SECURITIES & EXCHANGE COMMISSION
Washington, D.C. 20549
----------------------

SCHEDULE 13G*
(Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED
PURSUANT TO 13d-2(b)

Amendment No. 1

Access Pharmaceuticals, Inc.
(Name of Issuer)

Common Stock, $0.01 par value
(Title of Class of Securities)

00431M100
(CUSIP Number)

December 31, 2000
(Date of event which requires filing of this statement)


Check the appropriate box to designate the rule pursuant to which this
Schedule 13G is filed:

[ ] Rule 13d-1(b)
[X] Rule 13d-1(c)
[ ] Rule 13d-1(d)





(Page 1 of 11 Pages)
- ---------------
*The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act
of 1934 ("Act") or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see the
Notes).



CUSIP No. 00431M100 13G/A Page 2 of 11 Pages

- -----------------------------------------------------------------------------
(1) NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO.
OF ABOVE PERSONS (ENTITIES ONLY)
Oracle Partners, L.P.
- -----------------------------------------------------------------------------
(2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
(a) [X]
(b) [ ]
- -----------------------------------------------------------------------------
(3) SEC USE ONLY
- -----------------------------------------------------------------------------
(4) CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- -----------------------------------------------------------------------------
NUMBER OF (5) SOLE VOTING POWER
-0-
SHARES --------------------------------------------------------------

BENEFICIALLY (6) SHARED VOTING POWER
643,400
OWNED BY --------------------------------------------------------------

EACH (7) SOLE DISPOSITIVE POWER
-0-
REPORTING --------------------------------------------------------------

PERSON WITH (8) SHARED DISPOSITIVE POWER
643,400
- -----------------------------------------------------------------------------
(9) AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON
643,400
- -----------------------------------------------------------------------------
(10) CHECK BOX IF THE AGGREGATE AMOUNT
IN ROW (9) EXCLUDES CERTAIN SHARES ** [ ]
- -----------------------------------------------------------------------------
(11) PERCENT OF CLASS REPRESENTED
BY AMOUNT IN ROW (9)
5.0%
- -----------------------------------------------------------------------------
(12) TYPE OF REPORTING PERSON **
PN
- -----------------------------------------------------------------------------
** SEE INSTRUCTIONS BEFORE FILLING OUT!




CUSIP No. 00431M100 13G/A Page 3 of 11 Pages

- -----------------------------------------------------------------------------
(1) NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO.
OF ABOVE PERSONS (ENTITIES ONLY)
Oracle Institutional Partners, L.P.
- -----------------------------------------------------------------------------
(2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
(a) [X]
(b) [ ]
- -----------------------------------------------------------------------------
(3) SEC USE ONLY
- -----------------------------------------------------------------------------
(4) CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- -----------------------------------------------------------------------------
NUMBER OF (5) SOLE VOTING POWER
-0-
SHARES --------------------------------------------------------------

BENEFICIALLY (6) SHARED VOTING POWER
178,300
OWNED BY --------------------------------------------------------------

EACH (7) SOLE DISPOSITIVE POWER
-0-
REPORTING --------------------------------------------------------------

PERSON WITH (8) SHARED DISPOSITIVE POWER
178,300
- -----------------------------------------------------------------------------
(9) AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON
178,300
- -----------------------------------------------------------------------------
(10) CHECK BOX IF THE AGGREGATE AMOUNT
IN ROW (9) EXCLUDES CERTAIN SHARES ** [ ]
- -----------------------------------------------------------------------------
(11) PERCENT OF CLASS REPRESENTED
BY AMOUNT IN ROW (9)
1.4%
- -----------------------------------------------------------------------------
(12) TYPE OF REPORTING PERSON **
PN
- -----------------------------------------------------------------------------
** SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 00431M100 13G/A Page 4 of 11 Pages

- -----------------------------------------------------------------------------
(1) NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO.
OF ABOVE PERSONS (ENTITIES ONLY)
Oracle Investment Management, Inc.
- -----------------------------------------------------------------------------
(2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
(a) [X]
(b) [ ]
- -----------------------------------------------------------------------------
(3) SEC USE ONLY
- -----------------------------------------------------------------------------
(4) CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- -----------------------------------------------------------------------------
NUMBER OF (5) SOLE VOTING POWER
-0-
SHARES --------------------------------------------------------------

BENEFICIALLY (6) SHARED VOTING POWER
307,300
OWNED BY --------------------------------------------------------------

EACH (7) SOLE DISPOSITIVE POWER
-0-
REPORTING --------------------------------------------------------------

PERSON WITH (8) SHARED DISPOSITIVE POWER
307,300
- -----------------------------------------------------------------------------
(9) AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON
307,300
- -----------------------------------------------------------------------------
(10) CHECK BOX IF THE AGGREGATE AMOUNT
IN ROW (9) EXCLUDES CERTAIN SHARES ** [ ]
- -----------------------------------------------------------------------------
(11) PERCENT OF CLASS REPRESENTED
BY AMOUNT IN ROW (9)
2.4%
- -----------------------------------------------------------------------------
(12) TYPE OF REPORTING PERSON **
CO
- -----------------------------------------------------------------------------
** SEE INSTRUCTIONS BEFORE FILLING OUT!




CUSIP No. 00431M100 13G/A Page 5 of 11 Pages

- -----------------------------------------------------------------------------
(1) NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO.
OF ABOVE PERSONS (ENTITIES ONLY)
Oracle Associates, LLC
- -----------------------------------------------------------------------------
(2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
(a) [X]
(b) [ ]
- -----------------------------------------------------------------------------
(3) SEC USE ONLY
- -----------------------------------------------------------------------------
(4) CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
- -----------------------------------------------------------------------------
NUMBER OF (5) SOLE VOTING POWER
-0-
SHARES --------------------------------------------------------------

BENEFICIALLY (6) SHARED VOTING POWER
821,700
OWNED BY --------------------------------------------------------------

EACH (7) SOLE DISPOSITIVE POWER
-0-
REPORTING --------------------------------------------------------------

PERSON WITH (8) SHARED DISPOSITIVE POWER
821,700
- -----------------------------------------------------------------------------
(9) AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON
821,700
- -----------------------------------------------------------------------------
(10) CHECK BOX IF THE AGGREGATE AMOUNT
IN ROW (9) EXCLUDES CERTAIN SHARES ** [ ]
- -----------------------------------------------------------------------------
(11) PERCENT OF CLASS REPRESENTED
BY AMOUNT IN ROW (9)
6.4%
- -----------------------------------------------------------------------------
(12) TYPE OF REPORTING PERSON **
OO
- -----------------------------------------------------------------------------
** SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 00431M100 13G/A Page 6 of 11 Pages

- -----------------------------------------------------------------------------
(1) NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NO.
OF ABOVE PERSONS (ENTITIES ONLY)
Larry N. Feinberg
- -----------------------------------------------------------------------------
(2) CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP **
(a) [X]
(b) [ ]
- -----------------------------------------------------------------------------
(3) SEC USE ONLY
- -----------------------------------------------------------------------------
(4) CITIZENSHIP OR PLACE OF ORGANIZATION
United States
- -----------------------------------------------------------------------------
NUMBER OF (5) SOLE VOTING POWER
37,500
SHARES --------------------------------------------------------------

BENEFICIALLY (6) SHARED VOTING POWER
1,129,000
OWNED BY --------------------------------------------------------------

EACH (7) SOLE DISPOSITIVE POWER
37,500
REPORTING --------------------------------------------------------------

PERSON WITH (8) SHARED DISPOSITIVE POWER
1,129,000
- -----------------------------------------------------------------------------
(9) AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON
1,166,500
- -----------------------------------------------------------------------------
(10) CHECK BOX IF THE AGGREGATE AMOUNT
IN ROW (9) EXCLUDES CERTAIN SHARES ** [ ]
- -----------------------------------------------------------------------------
(11) PERCENT OF CLASS REPRESENTED
BY AMOUNT IN ROW (9)
9.1%
- -----------------------------------------------------------------------------
(12) TYPE OF REPORTING PERSON **
IN
- -----------------------------------------------------------------------------
** SEE INSTRUCTIONS BEFORE FILLING OUT!





CUSIP No. 00431M100 13G/A Page 7 of 11 Pages

Item 1(a). Name of Issuer:

The name of the issuer is Access Pharmaceuticals, Inc. (the "Company").

Item 1(b). Address of Issuer's Principal Executive Offices:

The Company's principal executive office is located at 2600 Stemmons
Freeway, Suite 176, Dallas, Texas 75207.


Item 2(a). Name of Person Filing:

This Amendment No. 1 to Schedule 13G ("Amendment No. 1") amends the
statement on Schedule 13G which was filed on April 12, 2000 with respect to the
Common Stock (as defined in Item 2(d) below) of the Company and is filed by:

(i) Oracle Partners, L.P., a Delaware limited partnership
("Oracle Partners"), with respect to shares of Common Stock
directly owned by it;

(ii) Oracle Institutional Partners, L.P., a Delaware limited
partnership ("Oracle Institutional"), with respect to shares
of Common Stock directly owned by it;

(iii) Oracle Investment Management, Inc., a Delaware corporation
(the "Investment Manager"), which serves as investment
manager to and has investment discretion over the securities
held by SAM Oracle Investments Inc., a British Virgin Islands
corporation ("SAM Oracle"), with respect to shares of Common
Stock directly owned by SAM Oracle, Oracle Offshore Limited,
a Cayman Islands corporation ("Oracle Offshore"), with
respect to shares of Common Stock directly owned by Oracle
Offshore, and Oracle Management, Inc. Employees Retirement
Plan (the "Retirement Plan"), with respect to shares of
Common Stock directly owned by the Retirement Plan;

(iv) Oracle Associates, LLC, a Delaware limited liability company
("Oracle Associates"), which serves as the general partner of
Oracle Partners and Institutional Partners (together, the
"Partnerships"), with respect to shares of Common Stock
directly owned by the Partnerships; and

(v) Mr. Larry N. Feinberg ("Mr. Feinberg"), which serves as the
senior managing member of Oracle Associates, is the sole
shareholder and president of the Investment Manager, and
is the trustee of The Feinberg Family Foundation (the
"Foundation"), with respect to shares of Common Stock
directly owned by him (for himself and as trustee of the
Foundation) and by the Partnerships, SAM Oracle, Oracle
Offshore, and the Retirement Plan.




CUSIP No. 00431M100 13G/A Page 8 of 11 Pages

The foregoing persons are hereinafter sometimes collectively referred to as
the "Reporting Persons." Any disclosures herein with respect to persons other
than the Reporting Persons are made on information and belief after making
inquiry to the appropriate party.

Item 2(b). Address of Principal Business Office or, if None, Residence:

The address of the principal business office of each of the Reporting
Persons is 712 Fifth Avenue, 45th Floor, New York, New York 10019.

Item 2(c). Citizenship:

Each of the Partnerships, the Investment Manager and Oracle Associates is
organized under the laws of the State of Delaware. Mr. Feinberg is a citizen of
the United States of America.

Item 2(d). Title of Class of Securities:

Common Stock, $0.01 par value ("Common Stock")

Item 2(e). CUSIP Number:

00431M100


Item 3. If this statement is filed pursuant to Rules 13d-1(b) or 13d-2(b)
or (c), check whether the person filing is a:

(a) [ ] Broker or dealer registered under Section 15 of the
Act,

(b) [ ] Bank as defined in Section 3(a)(6) of the Act,

(c) [ ] Insurance Company as defined in Section 3(a)(19) of
the Act,

(d) [ ] Investment Company registered under Section 8 of the
Investment Company Act of 1940,

(e) [ ] Investment Adviser in accordance with Rule
13d-1 (b)(1)(ii)(E),

(f) [ ] Employee Benefit Plan or Endowment Fund in accordance
with 13d-1 (b)(1)(ii)(F),

(g) [ ] Parent Holding Company or control person in accordance
with Rule 13d-1 (b)(1)(ii)(G),

(h) [ ] Savings Association as defined in Section 3(b) of the
Federal Deposit Insurance Act,

(i) [ ] Church Plan that is excluded from the definition of an
investment company under Section 3(c)(14) of the Investment
Company Act of 1940,




CUSIP No. 00431M100 13G/A Page 9 of 11 Pages

(j) [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

If this statement is filed pursuant to 13d-1(c), check this box: [x]

Item 4. Ownership.

A. Oracle Partners, L.P.
(a) Amount beneficially owned: 643,400
(b) Percent of class: 5.0% The percentages used herein and in the
rest of this Amendment No. 1 are calculated based upon the 12,783,225
shares of Common Stock issued and outstanding as of November 14, 2000,
as reflected in the Company's Form 10-Q for the period ending September
30, 2000.
(c) Number of shares as to which such person has:
(i) Sole power to vote or direct the vote: -0-
(ii) Shared power to vote or direct the vote: 643,400
(iii) Sole power to dispose or direct the disposition: -0-
(iv) Shared power to dispose or direct the disposition: 643,400

B. Oracle Institutional Partners, L.P.
(a) Amount beneficially owned: 178,300
(b) Percent of class: 1.4%
(c) Number of shares as to which such person has:
(i) Sole power to vote or direct the vote: -0-
(ii) Shared power to vote or direct the vote: 178,300
(iii) Sole power to dispose or direct the disposition: -0-
(iv) Shared power to dispose or direct the disposition: 178,300

C. Oracle Investment Management, Inc.
(a) Amount beneficially owned: 307,300
(b) Percent of class: 2.4%
(c) Number of shares as to which such person has:
(i) Sole power to vote or direct the vote: -0-
(ii) Shared power to vote or direct the vote: 307,300
(iii) Sole power to dispose or direct the disposition: -0-
(iv) Shared power to dispose or direct the disposition: 307,300

D. Oracle Associates, LLC
(a) Amount beneficially owned: 821,700
(b) Percent of class: 6.4%
(c) Number of shares as to which such person has:
(i) Sole power to vote or direct the vote: -0-
(ii) Shared power to vote or direct the vote: 821,700
(iii) Sole power to dispose or direct the disposition: -0-
(iv) Shared power to dispose or direct the disposition: 821,700

E. Larry N. Feinberg
(a) Amount beneficially owned: 1,166,500
(b) Percent of class: 9.1%
(c) Number of shares as to which such person has:
(i) Sole power to vote or direct the vote: 37,500
(ii) Shared power to vote or direct the vote: 1,129,000
(iii) Sole power to dispose or direct the disposition: 37,500
(iv) Shared power to dispose or direct the disposition:1,129,000




CUSIP No. 00431M100 13G/A Page 10 of 11 Pages

Item 5. Ownership of Five Percent or Less of a Class.

Not applicable.

Item 6. Ownership of More than Five Percent on Behalf of Another Person.

SAM Oracle, Oracle Offshore and the Retirement Plan, each clients of the
Investment Manager, have the right to receive and the power to direct the
receipt of dividends from, and proceeds from the sale of, the securities
reported in this Amendment No. 1. No single client of the Investment Manager
holds more than five percent of the class of securities reported herein.


Item 7. Identification and Classification of the Subsidiary Which Acquired
the Security Being Reported on by the Parent Holding Company.

Not applicable.


Item 8. Identification and Classification of Members of the Group.

Not applicable.


Item 9. Notice of Dissolution of Group.

Not applicable.

Item 10. Certification.

Each of the Reporting Persons hereby makes the following certification:

By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.





CUSIP No. 00431M100 13G/A Page 11 of 11 Pages

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.


DATED: February 12, 2001

/s/ Larry N. Feinberg
--------------------------------------
Larry N. Feinberg, individually and
as senior managing member of
Oracle Associates, LLC, on behalf of
itself and as the general partner of
Oracle Partners, L.P. and
Oracle Institutional Partners, L.P.,
as president of
Oracle Investment Management, Inc., and
as trustee of
The Feinberg Family Foundation