Quarterly report pursuant to Section 13 or 15(d)

Stock Based Compensation and Restricted Stock Compensation (Details)

v3.5.0.2
Stock Based Compensation and Restricted Stock Compensation (Details) - USD ($)
 3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense     $ 3,894,000 $ 2,851,000
Directors and Employees [Member]        
Share-based Arrangements Awards Granted [Abstract]        
Stock options granted (in shares) 0 0 0 1,360,000
Stock Options [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense $ 917,000 $ 1,452,000 $ 3,894,000 $ 2,581,000
Share-based Arrangements Awards Granted [Abstract]        
Stock options granted (in shares) 0 0 1,440,000 1,815,000
Restricted Stock [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense $ 241,000 $ 1,892,000 $ 3,120,000 $ 2,960,000
Research and Development [Member] | Stock Options [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 274,000 142,000 937,000 246,000
Research and Development [Member] | Restricted Stock [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 0 138,000 200,000 228,000
General and Administrative [Member] | Stock Options [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 643,000 1,310,000 2,957,000 2,335,000
General and Administrative [Member] | Restricted Stock [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense $ 241,000 $ 1,754,000 $ 2,920,000 $ 2,732,000