| STOCK-BASED COMPENSATION | 
 NOTE
6 – STOCK-BASED COMPENSATION 
  
The
following table summarizes stock option-based compensation for the three and six months ended June 30, 2020 and 2019: 
  
SCHEDULE
OF STOCK BASED COMPENSATION  
 
    |   | 
  | 
    For
    the three 
    months ended 
    June 30, | 
  | 
  | 
    For
    the three 
    months ended 
    June 30, | 
  | 
  | 
    For
    the six 
    months ended 
    June 30, | 
  | 
  | 
    For
    the six 
    months ended 
    June 30, | 
  | 
 
    |   | 
  | 
    2020 | 
  | 
  | 
    2019 | 
  | 
  | 
    2020 | 
  | 
  | 
    2019 | 
  | 
 
    | Research and development | 
  | 
    $ | 
871,000 | 
  | 
  | 
    $ | 
1,009,000 | 
  | 
  | 
    $ | 
1,615,000 | 
  | 
  | 
    $ | 
2,041,000 | 
  | 
 
    | General and administrative | 
  | 
      | 
707,000 | 
  | 
  | 
      | 
669,000 | 
  | 
  | 
      | 
1,219,000 | 
  | 
  | 
      | 
1,740,000 | 
  | 
 
    | Stock option-based compensation expense
    included in operating expense | 
  | 
      | 
1,578,000 | 
  | 
  | 
      | 
1,678,000 | 
  | 
  | 
      | 
2,834,000 | 
  | 
  | 
      | 
3,781,000 | 
  | 
 
    |   | 
  | 
      | 
  | 
  | 
  | 
      | 
  | 
  | 
  | 
      | 
  | 
  | 
  | 
      | 
  | 
  | 
 
    | Total stock option-based compensation
    expense | 
  | 
      | 
1,578,000 | 
  | 
  | 
      | 
1,678,000 | 
  | 
  | 
      | 
2,834,000 | 
  | 
  | 
      | 
3,781,000 | 
  | 
 
    | Tax benefit | 
  | 
      | 
- | 
  | 
  | 
      | 
- | 
  | 
  | 
      | 
- | 
  | 
  | 
      | 
- | 
  | 
 
    | Stock option-based
    compensation expense, net of tax | 
  | 
    $ | 
1,578,000 | 
  | 
  | 
    $ | 
1,678,000 | 
  | 
  | 
    $ | 
2,834,000 | 
  | 
  | 
    $ | 
3,781,000 | 
  | 
 
 
   
  
Stock
Options: We estimate the fair value of each option award on the date of grant using the Black-Scholes option valuation model.
We then recognize the grant date fair value of each option as compensation expense ratably using the straight-line attribution
method over the service period (generally the vesting period). The Black-Scholes model incorporates the following assumptions: 
  
    |   | 
    ● | 
    Expected
    volatility – we estimate the volatility of our share price at the date of grant using a “look-back” period
    which coincides with the expected term, defined below. We believe using a “look-back” period which coincides with
    the expected term is the most appropriate measure for determining expected volatility. | 
 
    |   | 
    ● | 
    Expected
    term – we estimate the expected term using the “simplified” method, as outlined in Staff Accounting Bulletin
    No. 107, “Share-Based Payment.” | 
 
    |   | 
    ● | 
    Risk-free
    interest rate – we estimate the risk-free interest rate using the U.S. Treasury yield curve for periods equal to the
    expected term of the options in effect at the time of grant. | 
 
    |   | 
    ● | 
    Dividends
    – we use an expected dividend yield of zero because we have not declared or paid a cash dividend, nor do we have any
    plans to declare a dividend. | 
 
 
  
We
used the following weighted-average assumptions to estimate the fair value of the options granted for the periods indicated: 
  
SCHEDULE
OF WEIGHTED-AVERAGE ASSUMPTIONS TO ESTIMATE THE FAIR VALUE OF THE OPTIONS GRANTED  
 
    |   | 
  | 
    For
    the three  months ended  June 30, | 
  | 
  | 
    For
    the three  months ended  June 30, | 
  | 
  | 
    For
    the six  months ended  June 30, | 
  | 
  | 
    For
    the six  months ended  June 30, | 
  | 
 
    |   | 
  | 
    2020 | 
  | 
  | 
    2019 | 
  | 
  | 
    2020 | 
  | 
  | 
    2019 | 
  | 
 
    | Expected
    volatility | 
  | 
      | 
111% | 
 | 
  | 
      | 
108% | 
 | 
  | 
      | 
111% | 
 | 
  | 
      | 
108% | 
 | 
 
    | Expected term | 
  | 
      | 
6.25
                                         years | 
  | 
  | 
      | 
5
                                         years | 
  | 
  | 
      | 
6.25
                                         years | 
  | 
  | 
      | 
5
                                         years | 
  | 
 
    | Risk-free interest
    rate | 
  | 
      | 
0.23% | 
 | 
  | 
      | 
2.21% | 
 | 
  | 
      | 
0.30% | 
 | 
  | 
      | 
2.24% | 
 | 
 
    | Expected dividend yield | 
  | 
      | 
0% | 
 | 
  | 
      | 
0% | 
 | 
  | 
      | 
0% | 
 | 
  | 
      | 
0% | 
 | 
 
 
  
 The
following table summarizes the options granted for the periods indicated: 
  
SCHEDULE
OF OPTIONS ACTIVITY  
 
    |   | 
  | 
    For
    the three 
    months ended 
    June 30, | 
  | 
  | 
    For
    the three 
    months ended 
    June 30, | 
  | 
  | 
    For
    the six 
    months ended 
    June 30, | 
  | 
  | 
    For
    the six 
    months ended 
    June 30, | 
  | 
 
    |   | 
  | 
    2020 | 
  | 
  | 
    2019 | 
  | 
  | 
    2020 | 
  | 
  | 
    2019 | 
  | 
 
    | Options granted | 
  | 
      | 
1,897,119 | 
  | 
  | 
      | 
1,183,890 | 
  | 
  | 
      | 
3,073,046 | 
  | 
  | 
      | 
1,384,890 | 
  | 
 
    | Weighted-average: | 
  | 
      | 
  | 
  | 
  | 
      | 
  | 
  | 
  | 
      | 
  | 
  | 
  | 
      | 
  | 
  | 
 
    | Exercise price | 
  | 
    $ | 
2.83 | 
  | 
  | 
    $ | 
6.86 | 
  | 
  | 
    $ | 
2.30 | 
  | 
  | 
    $ | 
6.84 | 
  | 
 
    | Grant date fair
    value | 
  | 
    $ | 
2.36 | 
  | 
  | 
    $ | 
5.39 | 
  | 
  | 
    $ | 
1.92 | 
  | 
  | 
    $ | 
5.37 | 
  | 
 
 
  
Restricted
Common Stock: We granted 1,083,313
shares of restricted common stock during
the three and six months ended June 30, 2020. We did not grant any shares of restricted common stock to employees during the three
and six months ended June 30, 2019. The following table summarizes restricted common stock compensation expense for the three
and six months ended June 30, 2020 and 2019: 
  
SCHEDULE
OF RESTRICTED COMMON STOCK SHARE-BASED COMPENSATION  
 
    |   | 
  | 
    For
    the three 
    months ended 
    June 30, | 
  | 
  | 
    For
    the three 
    months ended 
    June 30, | 
  | 
  | 
    For
    the six 
    months ended 
    June 30, | 
  | 
  | 
    For
    the six 
    months ended 
    June 30, | 
  | 
 
    |   | 
  | 
    2020 | 
  | 
  | 
    2019 | 
  | 
  | 
    2020 | 
  | 
  | 
    2019 | 
  | 
 
    | Research and development | 
  | 
    $ | 
147,000 | 
  | 
  | 
    $ | 
- | 
  | 
  | 
    $ | 
472,000 | 
  | 
  | 
    $ | 
- | 
  | 
 
    | General and administrative | 
  | 
      | 
40,000 | 
  | 
  | 
      | 
78,000 | 
  | 
  | 
      | 
179,000 | 
  | 
  | 
      | 
250,000 | 
  | 
 
    | Restricted stock-based compensation
    expense included in operating expense | 
  | 
      | 
187,000 | 
  | 
  | 
      | 
78,000 | 
  | 
  | 
      | 
651,000 | 
  | 
  | 
      | 
250,000 | 
  | 
 
    |   | 
  | 
      | 
  | 
  | 
  | 
      | 
  | 
  | 
  | 
      | 
  | 
  | 
  | 
      | 
  | 
  | 
 
    | Total restricted stock-based compensation
    expense | 
  | 
      | 
187,000 | 
  | 
  | 
      | 
78,000 | 
  | 
  | 
      | 
651,000 | 
  | 
  | 
      | 
250,000 | 
  | 
 
    | Tax benefit | 
  | 
      | 
- | 
  | 
  | 
      | 
- | 
  | 
  | 
      | 
- | 
  | 
  | 
      | 
- | 
  | 
 
    | Restricted stock-based
    compensation expense, net of tax | 
  | 
    $ | 
187,000 | 
  | 
  | 
    $ | 
78,000 | 
  | 
  | 
    $ | 
651,000 | 
  | 
  | 
    $ | 
250,000 | 
  | 
 
 
  
 
  
 |