Form: 3

Initial statement of beneficial ownership of securities

June 10, 2008

EXHIBIT 99.1 EXPLANATION OF RESPONSES

Published on June 10, 2008


Exhibit 99.1

Explanation of Responses


(1) The general partner of Oracle Institutional Partners, L.P. ("Oracle
Institutional") is Oracle Associates, LLC ("Oracle Associates"). Mr. Larry
N. Feinberg ("Mr. Feinberg") serves as the senior managing member of Oracle
Associates. Any further transactions in securities of the issuer required
to be reported by Oracle Institutional will be reported in joint filings
with Mr. Feinberg on Form 4.

(2) The Warrants are exercisable in whole or in part, at any time or from time
to time (beginning on November 7, 2007), at the option of the holder until
November 10, 2013, at an exercise price of $3.50 per share, subject to
adjustment.

(3) Each share of Preferred Stock is convertible in whole or in part, at any
time or from time to time, at the option of the holder into 3,333.33 shares
of Common Stock, at an exercise price of $3.00 per share, subject to
adjustment.