Annual report pursuant to Section 13 and 15(d)

NATURE OF OPERATIONS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 1)

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NATURE OF OPERATIONS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 1) - USD ($)
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Total stock based compensation expense $ 8,178,000 $ 4,644,000 $ 4,829,000
Employee Stock Option [Member]      
Total stock based compensation expense 8,178,000 4,644,000 4,829,000
Tax benefit 0 0 0
Stock based compensation expense, net of tax 8,178,000 4,644,000 4,829,000
Restricted Stock [Member]      
Total stock based compensation expense 688,000 1,272,000 3,432,000
Tax benefit 0 0 0
Stock based compensation expense, net of tax 688,000 1,272,000 3,432,000
Research and development [Member] | Employee Stock Option [Member]      
Total stock based compensation expense 3,913,000 1,668,000 1,219,000
Research and development [Member] | Restricted Stock [Member]      
Total stock based compensation expense 0 0 200,000
General and administrative [Member] | Employee Stock Option [Member]      
Total stock based compensation expense 4,265,000 2,976,000 3,610,000
General and administrative [Member] | Restricted Stock [Member]      
Total stock based compensation expense 688,000 1,272,000 3,232,000
Operating Expense [Member] | Employee Stock Option [Member]      
Total stock based compensation expense 8,178,000 4,644,000 4,829,000
Operating Expense [Member] | Restricted Stock [Member]      
Total stock based compensation expense $ 688,000 $ 1,272,000 $ 3,432,000