Annual report pursuant to Section 13 and 15(d)

NATURE OF OPERATIONS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 1)

v3.19.1
NATURE OF OPERATIONS AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 1) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Total stock based compensation expense $ 8,178,000 $ 4,644,000 $ 4,829,000
Employee Stock Option [Member]      
Total stock based compensation expense 8,178,000 4,644,000 4,829,000
Tax benefit 0 0 0
Stock based compensation expense, net of tax 8,178,000 4,644,000 4,829,000
Restricted Stock [Member]      
Total stock based compensation expense 688,000 1,272,000 3,432,000
Tax benefit 0 0 0
Stock based compensation expense, net of tax 688,000 1,272,000 3,432,000
Research and development [Member] | Employee Stock Option [Member]      
Total stock based compensation expense 3,913,000 1,668,000 1,219,000
Research and development [Member] | Restricted Stock [Member]      
Total stock based compensation expense 0 0 200,000
General and administrative [Member] | Employee Stock Option [Member]      
Total stock based compensation expense 4,265,000 2,976,000 3,610,000
General and administrative [Member] | Restricted Stock [Member]      
Total stock based compensation expense 688,000 1,272,000 3,232,000
Operating Expense [Member] | Employee Stock Option [Member]      
Total stock based compensation expense 8,178,000 4,644,000 4,829,000
Operating Expense [Member] | Restricted Stock [Member]      
Total stock based compensation expense $ 688,000 $ 1,272,000 $ 3,432,000