| Quarterly Financial Data (Unaudited) | NOTE 11 – QUARTERLY FINANCIAL DATA
(UNAUDITED)   The following table contains quarterly
financial information for 2019 and 2018. We believe that the following information reflects all normal recurring adjustments necessary
for a fair statement of the information for the periods presented. The operating results for any quarter are not necessarily indicative
of results for any future period.   
    |  |  | Quarters Ended |  |  
    |  |  | December 31, 2019
 |  |  | September 30, 2019
 |  |  | June 30, 2019
 |  |  | March 31, 2019
 |  |  
    | Foundation revenues |  | $ | - |  |  | $ | - |  |  | $ | - |  |  | $ | - |  |  
    | Royalties |  |  | - |  |  |  | - |  |  |  | - |  |  |  | - |  |  
    | Research and development |  |  | 9,605,000 |  |  |  | 10,917,000 |  |  |  | 16,307,000 |  |  |  | 11,737,000 |  |  
    | General and administrative |  |  | 4,734,000 |  |  |  | 4,700,000 |  |  |  | 5,612,000 |  |  |  | 5,659,000 |  |  
    | Loss from operations |  |  | (16,411,000 | ) |  |  | (17,649,000 | ) |  |  | (23,976,000 | ) |  |  | (19,054,000 | ) |  
    | Net loss |  |  | (16,431,000 | ) |  |  | (17,372,000 | ) |  |  | (23,924,000 | ) |  |  | (18,555,000 | ) |  
    | Basic and diluted loss per common share |  |  | (0.30 | ) |  |  | (0.35 | ) |  |  | (0.49 | ) |  |  | (0.39 | ) |  
    | Weighted average number of common shares outstanding – basic and diluted |  |  | 54,718,776 |  |  |  | 49,721,753 |  |  |  | 48,961,988 |  |  |  | 47,948,421 |  |    
    |  |  | Quarters Ended |  |  |  
    |  |  |  | December 31, 2018
 |  |  |  | September 30, 2018
 |  |  |  | June 30, 2018
 |  |  |  | March 31, 2018
 |  |  
    | Foundation revenues |  | $ | 369,000 |  |  | $ | 1,687,000 |  |  | $ | 259,000 |  |  | $ | 481,000 |  |  
    | Royalties |  |  | 113,000 |  |  |  | 22,000 |  |  |  | 17,000 |  |  |  | 50,000 |  |  
    | Research and development |  |  | 9,470,000 |  |  |  | 13,150,000 |  |  |  | 7,916,000 |  |  |  | 8,162,000 |  |  
    | General and administrative |  |  | 7,631,000 |  |  |  | 4,970,000 |  |  |  | 4,627,000 |  |  |  | 2,878,000 |  |  
    | Loss from operations |  |  | (18,010,000 | ) |  |  | (16,916,000 | ) |  |  | (12,557,000 | ) |  |  | (10,683,000 | ) |  
    | Net loss |  |  | (17,479,000 | ) |  |  | (16,419,000 | ) |  |  | (12,243,000 | ) |  |  | (10,530,000 | ) |  
    | Basic and diluted loss per common share |  |  | (0.36 | ) |  |  | (0.34 | ) |  |  | (0.26 | ) |  |  | (0.22 | ) |  
    | Weighted average number of common shares outstanding – basic and diluted |  |  | 47,944,486 |  |  |  | 47,794,394 |  |  |  | 47,303,518 |  |  |  | 47,060,523 |  |  |