Annual report pursuant to Section 13 and 15(d)

Consolidated Statements of Stockholders' Equity

v3.20.1
Consolidated Statements of Stockholders' Equity - USD ($)
Common Stock [Member]
Additional Paid-in Capital [Member]
Accumulated Deficit [Member]
Total
Beginning balance at Dec. 31, 2016 $ 403,000 $ 431,168,000 $ (332,473,000) $ 99,098,000
Beginning balance, shares at Dec. 31, 2016 40,254,457      
Stock option-based compensation expense 4,644,000 4,644,000
Restricted stock-based compensation expense 1,272,000 1,272,000
Issuance of common stock in connection with public offering, net of offering costs $ 58,000 86,116,000 86,174,000
Issuance of common stock in connection with public offering, net of offering costs, shares 5,750,000      
Issuance of common stock in connection with the exercise of stock options 344,000 344,000
Issuance of common stock in connection with the exercise of stock options, shares 81,719      
Issuance of common stock in connection with the exercise of $8.00 warrants $ 6,000 4,994,000 5,000,000
Issuance of common stock in connection with the exercise of $8.00 warrants, shares 625,000      
Issuance of common stock in connection with the exercise of $5.00 warrants $ 2,000 883,000 885,000
Issuance of common stock in connection with the exercise of $5.00 warrants, shares 176,932      
Net loss (27,319,000) (27,319,000)
Ending balance at Dec. 31, 2017 $ 469,000 529,421,000 (359,792,000) 170,098,000
Ending balance, shares at Dec. 31, 2017 46,888,108      
Cumulative effect adjustment of ASC 606 on January 1, 2018 6,275,000 6,275,000
Stock option-based compensation expense 8,178,000 8,178,000
Restricted stock-based compensation expense 688,000 688,000
Issuance of common stock in connection with the exercise of stock options $ 4,000 2,240,000 2,244,000
Issuance of common stock in connection with the exercise of stock options, shares 360,853      
Issuance of common stock in connection with the exercise of $5.00 warrants $ 6,000 3,227,000 3,233,000
Issuance of common stock in connection with the exercise of $5.00 warrants, shares 646,763      
Issuance of common stock in connection with cashless warrant exercises
Issuance of common stock in connection with cashless warrant exercises, shares 48,762      
Net loss (56,671,000) (56,671,000)
Ending balance at Dec. 31, 2018 $ 479,000 543,754,000 (410,188,000) 134,045,000
Ending balance, shares at Dec. 31, 2018 47,944,486      
Stock option-based compensation expense 7,338,000 7,338,000
Restricted stock-based compensation expense 899,000 899,000
Issuance of common stock and pre-funded warrants in connection with public offering, net of offering costs $ 324,000 95,648,000 95,972,000
Issuance of common stock and pre-funded warrants in connection with public offering, net of offering costs, shares 32,382,945      
Issuance of common stock under open market sale agreement $ 31,000 16,930,000 16,961,000
Issuance of common stock under open market sale agreement, shares 3,086,950      
Issuance of common stock in connection with the exercise of stock options $ 3,000 966,000 969,000
Issuance of common stock in connection with the exercise of stock options, shares 303,129      
Issuance of common stock in connection with restricted share awards $ 4,000 (4,000)
Issuance of common stock in connection with restricted share awards, shares 354,625      
Shares returned in connection with arbitration ruling on licensing agreement $ (5,000) (1,467,000) (1,472,000)
Shares returned in connection with arbitration ruling on licensing agreement, shares (450,000)      
Net loss (76,282,000) (76,282,000)
Ending balance at Dec. 31, 2019 $ 836,000 $ 664,064,000 $ (486,470,000) $ 178,430,000
Ending balance, shares at Dec. 31, 2019 83,622,135