Quarterly report pursuant to Section 13 or 15(d)

SCHEDULE OF STOCK OPTIONS ACTIVITY (Details)

v3.22.2.2
SCHEDULE OF STOCK OPTIONS ACTIVITY (Details) - USD ($)
 9 Months Ended 12 Months Ended
Sep. 30, 2022
Dec. 31, 2021
2015 Equity Incentive Plan [Member]    
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
Number of Options, Beginning balance 314,194  
Weighted- average exercise price, Beginning balance $ 38.48  
Weighted-average Remaining Contractual Term (years), Outstanding 6 years 8 months 15 days 7 years 7 months 17 days
Beginning balance, Options, Aggregate Intrinsic Value  
Number of Options, Granted 7,760  
Weighted- average exercise price, Granted $ 5.30  
Number of Options, Cancelled/forfeited (82,510)  
Weighted- average exercise price, Cancelled/forfeited $ 39.31  
Number of Options, Exercised  
Weighted- average exercise price, Exercised  
Number of Options, Ending balance 239,444 314,194
Weighted- average exercise price, Ending balance $ 37.10 $ 38.48
Beginning balance, Options, Aggregate Intrinsic Value
Number of Options, Exerciasble 140,414  
Weighted- average exercise price, Exercisable $ 36.67  
Weighted-average Remaining Contractual Term (years), Exercisable 5 years 4 months 20 days  
Aggregate Intrinsic Value, Exercisable  
Number of Options, Unvested options 99,030  
Weighted- average exercise price, Unvested options $ 37.72  
Weighted-average Remaining Contractual Term (years) 8 years 6 months 29 days  
Aggregate Intrinsic Value, Unvested  
Ending balance, Options, Aggregate Intrinsic Value
2005 Equity Incentive Plan [Member]    
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
Number of Options, Beginning balance 3,200  
Weighted- average exercise price, Beginning balance $ 32.00  
Weighted-average Remaining Contractual Term (years), Outstanding 1 year 14 days 1 year 9 months 18 days
Beginning balance, Options, Aggregate Intrinsic Value  
Number of Options, Cancelled/forfeited  
Weighted- average exercise price, Cancelled/forfeited  
Number of Options, Exercised  
Weighted- average exercise price, Exercised  
Number of Options, Ending balance 3,200 3,200
Weighted- average exercise price, Ending balance $ 32.00 $ 32.00
Beginning balance, Options, Aggregate Intrinsic Value
Number of Options, Exerciasble 3,200  
Weighted- average exercise price, Exercisable $ 32.00  
Weighted-average Remaining Contractual Term (years), Exercisable 1 year 14 days  
Aggregate Intrinsic Value, Exercisable  
Number of Options, Unvested options  
Weighted- average exercise price, Unvested options  
Aggregate Intrinsic Value, Unvested  
Ending balance, Options, Aggregate Intrinsic Value