Quarterly report pursuant to Section 13 or 15(d)

Stock Option Based Compensation and Restricted Stock Compensation (Details)

v3.7.0.1
Stock Option Based Compensation and Restricted Stock Compensation (Details) - USD ($)
 3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense     $ 2,735,000 $ 2,977,000
Restricted Stock [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense $ 324,000 $ 987,000 686,000 2,879,000
Restricted Stock [Member] | Research and Development Expense [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 0 62,000 0 200,000
Restricted Stock [Member] | General and Administrative [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 324,000 925,000 686,000 2,679,000
Employee Stock Option [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 1,243,000 1,385,000 2,735,000 2,977,000
Employee Stock Option [Member] | Research and Development Expense [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 368,000 314,000 724,000 664,000
Employee Stock Option [Member] | General and Administrative [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense $ 875,000 $ 1,071,000 $ 2,011,000 $ 2,313,000