Quarterly report pursuant to Section 13 or 15(d)

Stock Option-Based Compensation and Restricted Stock Compensation (Details)

v3.8.0.1
Stock Option-Based Compensation and Restricted Stock Compensation (Details) - USD ($)
 3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense     $ 3,527,000 $ 3,894,000
Stock Options [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense $ 792,000 $ 917,000 3,527,000 3,894,000
Stock Options [Member] | Research and Development Expense [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 394,000 274,000 1,118,000 937,000
Stock Options [Member] | General and Administrative [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 398,000 643,000 2,409,000 2,957,000
Restricted Stock [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 293,000 241,000 979,000 3,120,000
Restricted Stock [Member] | Research and Development Expense [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 0 0 0 200,000
Restricted Stock [Member] | General and Administrative [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense $ 293,000 $ 241,000 $ 979,000 $ 2,920,000