Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY

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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
Total
Warrants Exercise One [Member]
Warrants Exercise Two [Member]
Common Stock Issuance One [Member]
Common Stock Issuance Two [Member]
Employees and Directors [Member]
Common Stock [Member]
Common Stock [Member]
Warrants Exercise One [Member]
Common Stock [Member]
Warrants Exercise Two [Member]
Common Stock [Member]
Common Stock Issuance One [Member]
Common Stock [Member]
Common Stock Issuance Two [Member]
Common Stock [Member]
Employees and Directors [Member]
Additional Paid-in Capital [Member]
Additional Paid-in Capital [Member]
Warrants Exercise One [Member]
Additional Paid-in Capital [Member]
Warrants Exercise Two [Member]
Additional Paid-in Capital [Member]
Common Stock Issuance One [Member]
Additional Paid-in Capital [Member]
Common Stock Issuance Two [Member]
Additional Paid-in Capital [Member]
Employees and Directors [Member]
Accumulated deficit [Member]
Accumulated deficit [Member]
Warrants Exercise One [Member]
Accumulated deficit [Member]
Warrants Exercise Two [Member]
Accumulated deficit [Member]
Common Stock Issuance One [Member]
Accumulated deficit [Member]
Common Stock Issuance Two [Member]
Accumulated deficit [Member]
Employees and Directors [Member]
Balance at Dec. 31, 2015 $ 67,721,000           $ 328,000           $ 377,993,000           $ (310,600,000)          
Balance (in shares) at Dec. 31, 2015             32,743,013                                  
Restricted common stock issued 150,000         $ 3,432,000 $ 0         $ 1,000 150,000         $ 3,431,000 0         $ 0
Restricted common stock issued (in shares)             52,690         100,000                        
Exercise of $5.00 warrants   $ 0           $ 0           $ 0           $ 0        
Exercise of $5.00 warrants (in shares)               5,836                                
Common stock issued for services 2,452,000           $ 8,000           2,444,000           0          
Common stock issued for services (in shares)             750,000                                  
Common stock issued for an average, net of costs       $ 969,000 $ 41,068,000         $ 2,000 $ 63,000         $ 967,000 $ 41,005,000         $ 0 $ 0  
Common stock issued for an average, net of costs (in shares)                   158,029 6,293,889                          
Common stock issued for cash exercise of options 350,000           $ 1,000           349,000           0          
Common stock issued for cash exercise of options (in shares)             151,000                                  
Stock option compensation expense 4,829,000           $ 0           4,829,000           0          
Net loss (21,873,000)           0           0           (21,873,000)          
Balance at Dec. 31, 2016 99,098,000           $ 403,000           431,168,000           (332,473,000)          
Balance (in shares) at Dec. 31, 2016             40,254,457                                  
Restricted common stock issued           $ 1,272,000           $ 0           $ 1,272,000           $ 0
Restricted common stock issued (in shares)                       0                        
Exercise of $8.00 warrants   $ 5,000,000           $ 6,000           $ 4,994,000           $ 0        
Exercise of $8.00 warrants (in shares)               625,000                                
Exercise of $5.00 warrants     $ 885,000           $ 2,000           $ 883,000           $ 0      
Exercise of $5.00 warrants (in shares)                 176,932                              
Common stock issued for an average, net of costs       $ 86,174,000           $ 58,000           $ 86,116,000           $ 0    
Common stock issued for an average, net of costs (in shares)                   5,750,000                            
Common stock issued for cash exercise of options 344,000           $ 0           344,000           0          
Common stock issued for cash exercise of options (in shares)             81,719                                  
Stock option compensation expense 4,644,000           $ 0           4,644,000           0          
Net loss (27,319,000)           0           0           (27,319,000)          
Balance at Dec. 31, 2017 $ 170,098,000           $ 469,000           $ 529,421,000           $ (359,792,000)          
Balance (in shares) at Dec. 31, 2017             46,888,108