Quarterly report pursuant to Section 13 or 15(d)

Stock Based Option Compensation and Restricted Stock Compensation (Details)

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Stock Based Option Compensation and Restricted Stock Compensation (Details) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense     $ 4,573,000 $ 2,735,000
Stock Options [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense $ 2,673,000 $ 1,243,000 4,573,000 2,735,000
Stock Options [Member] | Research and Development Expense [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 900,000 368,000 1,744,000 724,000
Stock Options [Member] | General and Administrative [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 1,773,000 875,000 2,829,000 2,011,000
Restricted Stock [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 172,000 324,000 344,000 686,000
Restricted Stock [Member] | Research and Development Expense [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 0 0 0 0
Restricted Stock [Member] | General and Administrative [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense $ 172,000 $ 324,000 $ 344,000 $ 686,000