Quarterly report pursuant to Section 13 or 15(d)

Stock Based Option Compensation and Restricted Stock Compensation (Details)

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Stock Based Option Compensation and Restricted Stock Compensation (Details) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense     $ 7,072,000 $ 3,527,000
Stock Options [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense $ 2,499,000 $ 792,000 7,072,000 3,527,000
Stock Options [Member] | Research and Development Expense [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 1,012,000 394,000 2,756,000 1,118,000
Stock Options [Member] | General and Administrative [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 1,487,000 398,000 4,316,000 2,409,000
Restricted Stock [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense 172,000 293,000 516,000 979,000
Restricted Stock [Member] | General and Administrative [Member]        
Share-based and Restricted Stock Compensation Expense [Abstract]        
Stock-based compensation expense included in operating expense $ 172,000 $ 293,000 $ 516,000 $ 979,000